p-(Trifluoromethoxy)phenol → HCID 86665954, 화합물

반응식

[CH2:1]([O:3][C:4](=[O:13])[C:5]1[CH:10]=[CH:9][C:8](Cl)=[N:7][C:6]=1[Cl:12])[CH3:2].[F:14][C:15]([F:25])([F:24])[O:16][C:17]1[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=1>>[CH2:1]([O:3][C:4](=[O:13])[C:5]1[CH:10]=[CH:9][C:8]([O:23][C:20]2[CH:21]=[CH:22][C:17]([O:16][C:15]([F:14])([F:24])[F:25])=[CH:18][CH:19]=2)=[N:7][C:6]=1[Cl:12])[CH3:2]

참가 물질

반응물 2

HCID 70015p-(Trifluoromethoxy)phenol

HCID 12263987Ethyl 2,6-dichloronicotinate

생성물 1

HCID 86665954HCID 86665954, 화합물수율 829.4%

실험 절차

2,6-dichloronicotinic acid ethyl ester (0.22 g, 0.1 mmol) and 4-trifluoromethoxy-phenol (0.178 g, 0.1 mmol) were coupled using the procedure of Example 17(a) to afford 0.3 g of the required produCt. Percentage purity (LCMS): 64.0%.

출처 및 근거

ORD 기록: ord-a36f40e1fb1b4e1dbd607af5a6c56df2
출처 데이터셋: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08722930B2

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