4-(2-Aminoethyl)piperidine, 4-BOC protected → HCID 66818826, 화합물

반응식

[C:1]([C:3]1[CH:19]=[CH:18][C:6]([O:7][C:8]2[CH:9]=[C:10]([CH:14]=[C:15]([OH:17])[CH:16]=2)[C:11]([OH:13])=O)=[CH:5][CH:4]=1)#[N:2].[C:20]([O:24][C:25](=[O:35])[NH:26][CH2:27][CH2:28][CH:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1)([CH3:23])([CH3:22])[CH3:21]>>[C:20]([O:24][C:25](=[O:35])[NH:26][CH2:27][CH2:28][CH:29]1[CH2:30][CH2:31][N:32]([C:11](=[O:13])[C:10]2[CH:14]=[C:15]([OH:17])[CH:16]=[C:8]([O:7][C:6]3[CH:5]=[CH:4][C:3]([C:1]#[N:2])=[CH:19][CH:18]=3)[CH:9]=2)[CH2:33][CH2:34]1)([CH3:23])([CH3:21])[CH3:22]

참가 물질

반응물 2

HCID 15018494-(2-Aminoethyl)piperidine, 4-BOC protected

HCID 66818647HCID 66818647, 화합물

생성물 1

HCID 66818826HCID 66818826, 화합물수율 68.5%

실험 절차

Following the procedure of Example 9(e) 3-(4-cyano phenoxy)-5-hydroxy benzoic acid 1.6 g (6.3 mmol) and (2-piperidin-4-yl-ethyl)-carbamic acid tert-butyl ester (1.43 g, 6.27 mmol) were used to afford 2.0 g of the required product. Percentage purity (LCMS): 79.6%, (M+1)=465.2+1.

출처 및 근거

ORD 기록: ord-2f50010834674fb5808b4c994bce7a73
출처 데이터셋: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08722930B2

반응 노트

불러오는 중…