HCID 66818846, 화합물 → HCID 178453961, 화합물

HRID 1024802노트

반응식

HRID 1024802 반응식
[C:1]([O:5][C:6]([NH:8][C@@H:9]1[CH2:14][CH2:13][C@H:12]([C:15]([OH:17])=O)[CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:18]([C:20]1[CH:42]=[CH:41][C:23]([O:24][C:25]2[CH:26]=[C:27]([NH2:40])[CH:28]=[C:29]([O:31][C:32]3[CH:37]=[CH:36][C:35]([C:38]#[N:39])=[CH:34][CH:33]=3)[CH:30]=2)=[CH:22][CH:21]=1)#[N:19]>>[C:1]([O:5][C:6](=[O:7])[NH:8][C@H:9]1[CH2:10][CH2:11][C@@H:12]([C:15](=[O:17])[NH:40][C:27]2[CH:28]=[C:29]([O:31][C:32]3[CH:37]=[CH:36][C:35]([C:38]#[N:39])=[CH:34][CH:33]=3)[CH:30]=[C:25]([O:24][C:23]3[CH:41]=[CH:42][C:20]([C:18]#[N:19])=[CH:21][CH:22]=3)[CH:26]=2)[CH2:13][CH2:14]1)([CH3:2])([CH3:3])[CH3:4]

참가 물질

3

반응물 2

HCID 66818846HCID 66818846, 화합물HCID 178453971HCID 178453971, 화합물

생성물 1

HCID 178453961HCID 178453961, 화합물수율 65.4%

실험 절차

Following the procedure of Example 9(e) cis-4-tert-butoxycarbonylamino-cyclo-hexanecarboxylic acid 1.0 g (4.15 mmol) and [3,5-bis-(4-cyano-phenoxy)-phenyl]-amine (1.34 g, 4.15 mmol) were used to afford 1.5 g of the required product. 1H NMR (DMSO-d6): δ 1.4 (9H, s), 2.3 (4H, m), 2.81 (1H, m), 3.15 (4H, m), 3.5 (1H, m), 6.71 (1H, s), 6.81 (1H, brs), 7.21 (6H, m), 7.92 (4H, d), 10.0 (1H, brs).

출처 및 근거

ORD 기록
ord-04d3bf6295b54d9cb7a739e63607bcdc
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08722930B2

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