(S)-(-)-2-(tert-Butoxycarbonylamino)-3-cyclohexyl-1-propanol → (2S,3S)-3-Amino-4-cyclohexyl-N-cyclopropyl-2-hydroxybutanamide dihydrochloride

HRID 1025306

반응식

HRID 1025306 반응식
[ClH:1].Cl.[NH2:3][C@@H:4]([CH2:13][CH3:14])[C@H:5]([OH:12])[C:6]([NH:8][CH:9]1[CH2:11][CH2:10]1)=[O:7].[CH:15]1(C[C@H](NC(=O)OC(C)(C)C)CO)[CH2:20][CH2:19]C[CH2:17][CH2:16]1>>[ClH:1].[ClH:1].[NH2:3][C@@H:4]([CH2:13][CH:14]1[CH2:19][CH2:20][CH2:15][CH2:16][CH2:17]1)[C@H:5]([OH:12])[C:6]([NH:8][CH:9]1[CH2:10][CH2:11]1)=[O:7]

참가 물질

3

반응물 2

HCID 11043405(S)-(-)-2-(tert-Butoxycarbonylamino)-3-cyclohexyl-1-propanolHCID 86762404(2S,3S)-3-amino-N-cyclopropyl-2-hydroxypentanamide dihydrochloride

생성물 1

HCID 86762409(2S,3S)-3-Amino-4-cyclohexyl-N-cyclopropyl-2-hydroxybutanamide dihydrochloride

실험 절차

The title compound was prepared in analogy to (2S,3S)-3-amino-N-cyclopropyl-2-hydroxypentanamide dihydrochloride, Representative Procedure A, starting with (S)-tert-butyl 1-cyclohexyl-3-hydroxypropan-2-ylcarbamate in the second step (A2).

출처 및 근거

ORD 기록
ord-cff7caca12fd44209ceacd655affce20
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08729061B2

연결된 노트

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