Tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine-1-carboxylate → tert-Butyl 4-(7-fluoro-2-(1-(5-propylpyrimidin-2-yl)piperidin-4-yl)-2,3-dihydrobenzofuran-5-yl)-5,6-dihydropyridine-1(2H)-carboxylate

반응식

BrC1C=C(F)C2OC(C3CCN(C4N=CC(CCC)=CN=4)CC3)CC=2C=1.CC1(C)C(C)(C)OB(C2CCN(C(OC(C)(C)C)=O)CC=2)O1.[F:49][C:50]1[C:58]2[O:57][CH:56]([C:59]3(O)[CH2:64][CH2:63][N:62]([C:65]4[N:70]=[CH:69][C:68]([CH2:71][CH2:72][CH3:73])=[CH:67][N:66]=4)[CH2:61][CH2:60]3)[CH2:55][C:54]=2[CH:53]=[C:52]([C:75]2[CH2:80][CH2:79][N:78]([C:81]([O:83][C:84]([CH3:87])([CH3:86])[CH3:85])=[O:82])[CH2:77][CH:76]=2)[CH:51]=1>>[F:49][C:50]1[C:58]2[O:57][CH:56]([CH:59]3[CH2:60][CH2:61][N:62]([C:65]4[N:70]=[CH:69][C:68]([CH2:71][CH2:72][CH3:73])=[CH:67][N:66]=4)[CH2:63][CH2:64]3)[CH2:55][C:54]=2[CH:53]=[C:52]([C:75]2[CH2:80][CH2:79][N:78]([C:81]([O:83][C:84]([CH3:85])([CH3:87])[CH3:86])=[O:82])[CH2:77][CH:76]=2)[CH:51]=1