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Trifluoroacetic acid → 4-(5-Bromo-2-methyl-2,3-dihydrobenzofuran-2-yl)piperidine

HRID 1025510
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인쇄 미리보기

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HRID 1025510 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH:11]3[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]3)([CH3:10])[CH2:7][C:6]=2[CH:24]=1.C(O)(C(F)(F)F)=O.FC1C2OC(C3(O)CCN(C4N=CC(CCC)=CN=4)CC3)CC=2C=C(C2CCNCC=2)C=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)([CH3:10])[CH2:7][C:6]=2[CH:24]=1
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참가 물질

4

반응물 3

HCID 6422Trifluoroacetic acidHCID 674657764-(7-Fluoro-5-(1,2,3,6-tetrahydropyridin-4-yl)-2,3-dihydrobenzofuran-2-yl)-1-(5-propylpyrimidin-2-yl)piperidin-4-olHCID 68211517tert-Butyl 4-(5-bromo-2-methyl-2,3-dihydrobenzofuran-2-yl)piperidine-1-carboxylate

생성물 1

HCID 674657574-(5-Bromo-2-methyl-2,3-dihydrobenzofuran-2-yl)piperidine

실험 절차

Compound 11D was prepared from Compound 11C and TFA in a similar manner to the procedure described for Compound 1J in Example 1. LC/MS (m/z)=296 (M+H)+.

출처 및 근거

ORD 기록
ord-c0918c4f6fe349bbb53ecd9adc5be44e
출처 데이터셋
uspto-grants-2014_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08729084B2

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