Isopropylamine → 2-acetamido-4-(N-isopropylamino)-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine

HRID 1025519노트

반응식

HRID 1025519 반응식
[C:1]([NH:4][C:5]1[N:6]=[C:7](C2N=CNN=2)[C:8]2[N:14]=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=3)[CH:12]=[CH:11][C:9]=2[N:10]=1)(=[O:3])[CH3:2].[CH:27]([NH2:30])([CH3:29])[CH3:28]>O1CCOCC1>[C:1]([NH:4][C:5]1[N:6]=[C:7]([NH:30][CH:27]([CH3:29])[CH3:28])[C:8]2[N:14]=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=3)[CH:12]=[CH:11][C:9]=2[N:10]=1)(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 6363IsopropylamineHCID 178474430HCID 178474430, 화합물

생성물 1

HCID 690791042-acetamido-4-(N-isopropylamino)-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine수율 73%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To a suspension of the 2-acetamido-4-(1,2,4-triazolyl)-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine of example 2 (70 mg) in dioxane (5 ml) was added isopropylamine (0.4 mmol). The reaction was stirred at room temperature for 24 hours. The solvents were evaporated in vacuo, yielding the crude title compound which was purified by preparative TLC on silica, using a mixture of methanol and dichloromethane, in a ratio of 10:90 as mobile phase, thus providing the title compound in 73% yield. The pure title compound was characterized by its mass spectrum as follows: MS (m/z): 340 ([M+H]+, 100).

후처리

  1. customThe solvents were evaporated in vacuo
  2. customyielding the crude title compound which
  3. customwas purified by preparative TLC on silica
  4. additiona mixture of methanol and dichloromethane

출처 및 근거

ORD 기록
ord-9255a2db6ce149ababd4486365ebb536
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08729089B2

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