2-acetamido-4-(N-isopropylamino)-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine → 2-amino-4-(N-isopropylamino)-6-(4-fluorophenyl)pyrido-[3,2-d]pyrimidine

HRID 1025520노트

반응식

HRID 1025520 반응식
C([NH:4][C:5]1[N:6]=[C:7]([NH:22][CH:23]([CH3:25])[CH3:24])[C:8]2[N:14]=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=3)[CH:12]=[CH:11][C:9]=2[N:10]=1)(=O)C>ClCCl.[O-]CC.[Na+]>[NH2:4][C:5]1[N:6]=[C:7]([NH:22][CH:23]([CH3:25])[CH3:24])[C:8]2[N:14]=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=3)[CH:12]=[CH:11][C:9]=2[N:10]=1

참가 물질

4

반응물 1

HCID 690791042-acetamido-4-(N-isopropylamino)-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine

생성물 1

HCID 690788992-amino-4-(N-isopropylamino)-6-(4-fluorophenyl)pyrido-[3,2-d]pyrimidine수율 61%

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 2723922Sodium ethoxide용매

실험 절차

The crude 2-acetamido-4-(N-isopropylamino)-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine of example 3 (0.5 mmol) was suspended in a mixture of dichloromethane (10 ml) and 0.5 N sodium ethoxide (10 ml). The reaction mixture was stirred for 16 hours at room temperature. The solvents were evaporated in vacuo and the crude residue was purified by preparative thin layer chromatography on silica, using a mixture of methanol and dichloromethane (in a volume ratio of 10:90) as a mobile phase providing, in a yield of 61%, the pure title compound which was characterized by its mass spectra as follows: MS (m/z): 298 ([M+H]+, 100).

후처리

  1. customThe solvents were evaporated in vacuo
  2. customthe crude residue was purified by preparative thin layer chromatography on silica
  3. additiona mixture of methanol and dichloromethane (in a volume ratio of 10:90) as a mobile phase
  4. customproviding, in a yield of 61%

출처 및 근거

ORD 기록
ord-40a2ec3b4a874195beecdd7ae42d7a90
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08729089B2

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