Potassium Carbonate → N-(4-bromophenyl)-2-(4-ethyl-4-isopropyl-2,5-dioxoimidazolidin-1-yl)acetamide

HRID 1025533노트

반응식

HRID 1025533 반응식
[CH2:1]([C:3]1([CH:10]([CH3:12])[CH3:11])[NH:7][C:6](=[O:8])[NH:5][C:4]1=[O:9])[CH3:2].[Br:13][C:14]1[CH:19]=[CH:18][C:17]([NH:20][C:21](=[O:24])[CH2:22]Cl)=[CH:16][CH:15]=1.C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[Br:13][C:14]1[CH:15]=[CH:16][C:17]([NH:20][C:21](=[O:24])[CH2:22][N:5]2[C:4](=[O:9])[C:3]([CH2:1][CH3:2])([CH:10]([CH3:11])[CH3:12])[NH:7][C:6]2=[O:8])=[CH:18][CH:19]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 17374N-(4-Bromophenyl)-2-chloroacetamideHCID 2345135-Ethyl-5-(propan-2-yl)imidazolidine-2,4-dione

생성물 1

HCID 71664632N-(4-bromophenyl)-2-(4-ethyl-4-isopropyl-2,5-dioxoimidazolidin-1-yl)acetamide

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 5-Ethyl-5-(1-methylethyl)-2,4-imidazolidinedione, (CAS #98492-91-2 (50 mg, 0.29 mmol), N-(4-bromophenyl)-2-chloro-acetamide (CAS #2564-02-5) (80 mg, 0.32 mmol), K2CO3 (48 mg, 0.35 mmol) in acetone was stirred at ambient temperature for 18 h. The mixture was extracted with EtOAc, the organic layer was washed with brine, dried over MgSO4, filtered and solvent removed. The crude product was purified by preparative TLC. The title compound was isolated as white solid.

후처리

  1. extractionThe mixture was extracted with EtOAc
  2. washthe organic layer was washed with brine
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. customsolvent removed
  6. customThe crude product was purified by preparative TLC

출처 및 근거

ORD 기록
ord-3440bad861ec4af0aaf44df09e30acfb
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08729096B2

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