cis-1,2,3,6-Tetrahydrophthalimide → 1H-Isoindole-1,3(2H)-dione, hexahydro-

HRID 1025539

반응식

HRID 1025539 반응식
[C:1]1(=[O:11])[C@@H:9]2[C@@H:4]([CH2:5][CH:6]=[CH:7][CH2:8]2)[C:3](=[O:10])[NH:2]1>CO.[Pd]>[C:1]1(=[O:11])[CH:9]2[CH:4]([CH2:5][CH2:6][CH2:7][CH2:8]2)[C:3](=[O:10])[NH:2]1

참가 물질

4

반응물 1

HCID 92888cis-1,2,3,6-Tetrahydrophthalimide

생성물 1

HCID 735591H-Isoindole-1,3(2H)-dione, hexahydro-수율 85.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of (3aR,7aS)-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione (3.0 g, 19.9 mmol) and 10% Pd/C (300 mg) in MeOH (100 mL) was shaken in an H2 atmosphere (300 psi) in a Parr apparatus for 24 h. The reaction mixture was filtrated and the liquids concentrated to dryness, affording the title compound (2.6 g, 16.99 mmol), that was sued without any further purification, as a white powder.

후처리

  1. filtrationThe reaction mixture was filtrated
  2. concentrationthe liquids concentrated to dryness

출처 및 근거

ORD 기록
ord-eebc4f521baf4b0f85da8ce609a1ac54
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08729098B2

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