4-(1-Hydroxy-4-oxocyclohexyl)benzonitrile → 6-(1-Hydroxy-4-oxocyclohexyl)nicotinonitrile

HRID 1025713노트

반응식

HRID 1025713 반응식
[OH:1][C:2]1([C:12]2[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][N:13]=2)[CH2:11][CH2:10][C:5]2(OCC[O:6]2)[CH2:4][CH2:3]1.OC1(C2C=CC(C#N)=CC=2)CCC(=O)CC1>>[OH:1][C:2]1([C:12]2[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][N:13]=2)[CH2:11][CH2:10][C:5](=[O:6])[CH2:4][CH2:3]1

참가 물질

3

반응물 2

HCID 667872294-(1-Hydroxy-4-oxocyclohexyl)benzonitrileHCID 667877276-(8-Hydroxy-1,4-dioxaspiro[4.5]dec-8-yl)nicotinonitrile

생성물 1

HCID 667880036-(1-Hydroxy-4-oxocyclohexyl)nicotinonitrile

실험 절차

The title compound was synthesized from 6-(8-hydroxy-1,4-dioxaspiro[4.5]dec-8-yl)nicotinonitrile using the sane typical deprotection procedure as for 4-(1-hydroxy-4-oxocyclohexyl)benzonitrile.

출처 및 근거

ORD 기록
ord-71659a52cb914868ac2a628d3e74363d
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08729063B2

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