Boronic acid, (4-ethylphenyl)- → 5-(4-Ethylphenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid

HRID 1025985

반응식

HRID 1025985 반응식
Br[C:2]1[CH:3]=[C:4]([C:14]([OH:16])=[O:15])[CH:5]=[N:6][C:7]=1[O:8][CH2:9][C:10]([F:13])([F:12])[F:11].[CH2:17]([C:19]1[CH:24]=[CH:23][C:22](B(O)O)=[CH:21][CH:20]=1)[CH3:18]>>[CH2:17]([C:19]1[CH:24]=[CH:23][C:22]([C:2]2[C:7]([O:8][CH2:9][C:10]([F:13])([F:12])[F:11])=[N:6][CH:5]=[C:4]([CH:3]=2)[C:14]([OH:16])=[O:15])=[CH:21][CH:20]=1)[CH3:18]

참가 물질

3

반응물 2

HCID 2734352Boronic acid, (4-ethylphenyl)-HCID 581925925-Bromo-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid

생성물 1

HCID 666784865-(4-Ethylphenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid

실험 절차

The title compound was synthesized in analogy to Example BQ using 5-bromo-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid (CAN 1211586-75-2) and B-(4-ethylphenyl)-boronic acid, (CAN 63139-21-9) as starting materials; LC-MS (UV peak area/ESI) 95.8%, 324.0859 (M−H)−.

출처 및 근거

ORD 기록
ord-c8e2f92284ad4f2e8a619e57b49bec6b
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08729105B2

연결된 노트

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