(4-Chloro-3-methylphenyl)boronic acid → 5-(4-Chloro-3-methylphenyl)-6-cyclobutoxynicotinic acid

HRID 1025992노트

반응식

HRID 1025992 반응식
Br[C:2]1[C:3]([O:11][CH:12]2[CH2:15][CH2:14][CH2:13]2)=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[Cl:16][C:17]1[CH:22]=[CH:21][C:20](B(O)O)=[CH:19][C:18]=1[CH3:26]>>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:2]2[C:3]([O:11][CH:12]3[CH2:15][CH2:14][CH2:13]3)=[N:4][CH:5]=[C:6]([CH:10]=2)[C:7]([OH:9])=[O:8])=[CH:19][C:18]=1[CH3:26]

참가 물질

3

반응물 2

HCID 3786632(4-Chloro-3-methylphenyl)boronic acidHCID 66678843HCID 66678843, 화합물

생성물 1

HCID 666784895-(4-Chloro-3-methylphenyl)-6-cyclobutoxynicotinic acid

실험 절차

The title compound was synthesized in analogy to Example BQ using 5-bromo-6-cyclobutoxy-nicotinic acid (example BY) and B-(4-chloro-3-methylphenyl)-boronic acid (CAN 161950-10-3) as starting materials; MS (ESI): 316.2 (M−H)−.

출처 및 근거

ORD 기록
ord-ee9761f07961498aa70963c0a6c8b2e8
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08729105B2

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