3,4-Difluorobenzeneboronic acid → HCID 66678797, 화합물

반응식

Br[C:2]1[CH:3]=[C:4]([C:13]([OH:15])=[O:14])[CH:5]=[N:6][C:7]=1[O:8][CH2:9][CH2:10][O:11][CH3:12].[F:16][C:17]1[CH:18]=[C:19](B(O)O)[CH:20]=[CH:21][C:22]=1[F:23]>>[F:16][C:17]1[CH:18]=[C:19]([C:2]2[C:7]([O:8][CH2:9][CH2:10][O:11][CH3:12])=[N:6][CH:5]=[C:4]([CH:3]=2)[C:13]([OH:15])=[O:14])[CH:20]=[CH:21][C:22]=1[F:23]

참가 물질

반응물 2

HCID 27343373,4-Difluorobenzeneboronic acid

HCID 211097055-Bromo-6-(2-methoxy-ethoxy)-nicotinic acid

생성물 1

HCID 66678797HCID 66678797, 화합물

실험 절차

The title compound was synthesized in analogy to Example BQ using 5-bromo-6-(2-methoxyethoxy)-3-pyridinecarboxylic acid (CAN 912454-34-3) and B-(3,4-difluorophenyl)-boronic acid, (CAN 168267-41-2) as starting materials; MS (ESI): 308.3 (M−H)−.

출처 및 근거

ORD 기록: ord-1acae6506b9541bab3d8191eeb25e498
출처 데이터셋: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08729105B2

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