4-Amino-3-nitrobenzimidamide hydrochloride → 3,4-Diaminobenzimidamide hydrochloride

HRID 1026196노트

반응식

HRID 1026196 반응식
[ClH:1].[NH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([NH2:9])=[NH:8])=[CH:5][C:4]=1[N+:12]([O-])=O>[OH-].[OH-].[Pd+2].CO>[ClH:1].[NH2:12][C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:3]=1[NH2:2])[C:7]([NH2:9])=[NH:8]

참가 물질

4

반응물 1

HCID 673560924-Amino-3-nitrobenzimidamide hydrochloride

생성물 1

HCID 221255323,4-Diaminobenzimidamide hydrochloride

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매2회HCID 887Methanol용매

실험 절차

A suspension of 4-amino-3-nitrobenzamidine monohydrochloride (15 g, 69 mmol) and Pearlman's catalyst [Pd(OH)2, 1.0 g, 7.12 mmol) in methanol (200 mL) was shaken under hydrogen atmosphere 50 psi for 1.5 h. The suspension was filtered through Celite and the filtrate was added dropwise to anhydrous diethyl ether (400 mL) to precipitate 3,4-diaminobenzamidine monohydrochloride as a tan solid.

후처리

  1. filtrationThe suspension was filtered through Celite
  2. additionthe filtrate was added dropwise to anhydrous diethyl ether (400 mL)
  3. customto precipitate 3,4-diaminobenzamidine monohydrochloride as a tan solid

출처 및 근거

ORD 기록
ord-ff68b3688fc54bdbb19cd8204f84dc29
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08729117B2

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