Trifluoroacetic acid → 2-[(2,5-Dichloropyridin-3-yl)oxy]-2-methylpropionic acid

HRID 1026539노트

반응식

HRID 1026539 반응식
[Cl:1][C:2]1[C:7]([O:8][C:9]([CH3:18])([CH3:17])[C:10]([O:12]C(C)(C)C)=[O:11])=[CH:6][C:5]([Cl:19])=[CH:4][N:3]=1.FC(F)(F)C(O)=O>ClCCl>[Cl:1][C:2]1[C:7]([O:8][C:9]([CH3:17])([CH3:18])[C:10]([OH:12])=[O:11])=[CH:6][C:5]([Cl:19])=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 86671386Tert-butyl 2-[(2,5-dichloropyridin-3-yl)oxy]-2-methylpropionate

생성물 1

HCID 866713872-[(2,5-Dichloropyridin-3-yl)oxy]-2-methylpropionic acid수율 125.5%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a dichloromethane solution (157 ml) of tert-butyl 2-[(2,5-dichloropyridin-3-yl)oxy]-2-methylpropionate (79.1 g) was added at 0° C. trifluoroacetic acid (157 ml). The reaction solution was brought back to room temperature, stirred overnight, and then concentrated under reduced pressure. The residue was dissolved in ethyl acetate, washed sequentially with water and saturated sodium chloride solution, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was azeotroped with toluene to afford 2-[(2,5-dichloropyridin-3-yl)oxy]-2-methylpropionic acid (81.1 g).

후처리

  1. customwas brought back to room temperature
  2. concentrationconcentrated under reduced pressure
  3. dissolutionThe residue was dissolved in ethyl acetate
  4. washwashed sequentially with water and saturated sodium chloride solution
  5. dry with materialdried over anhydrous sodium sulfate
  6. concentrationconcentrated under reduced pressure
  7. customThe residue was azeotroped with toluene

출처 및 근거

ORD 기록
ord-0b56ff09ed5144dda50816a792bad4d0
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08729095B2

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