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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 10267생성일: 2026년 10월 25일

Benzylsulfamic acid [5-(2-chloro-5-methoxy-phenoxy)-6-(2-hydroxy-ethoxy) pyrimidin-4-yl]-amide → Benzylsulfamic acid [6-[2-(5-methylsulfanyl-pyrimidin-2-yloxy)ethoxy]-5-(2-chloro-5-methoxy-phenoxy)pyrimidin-4-yl]-amide

https://huagongshe.com/reaction/10267

반응식

참여 물질

역할이름HCID투입량
반응물Benzylsulfamic acid [5-(2-chloro-5-methoxy-phenoxy)-6-(2-hydroxy-ethoxy) pyrimidin-4-yl]-amideHCID 21041229—
반응물2-Chloro-5-(methylthio)pyrimidineHCID 21979532—
생성물Benzylsulfamic acid [6-[2-(5-methylsulfanyl-pyrimidin-2-yloxy)ethoxy]-5-(2-chloro-5-methoxy-phenoxy)pyrimidin-4-yl]-amideHCID 2197956045.7%

반응 단계

Benzylsulfamic acid [6-[2-(5-methylsulfanyl-pyrimidin-2-yloxy)-ethoxy]-5-(2-chloro-5-methoxy-phenoxy)-pyrimidin-4-yl]-amide (138 mg) (Example 213) was prepared from benzylsulfamic acid [5-(2-chloro-5-methoxy-phenoxy)-6-(2-hydroxy-ethoxy)-pyrimidin-4-yl]-amide (240 mg) (Example 211) and 5-methylsulfanyl-2-chloropyrimidine (180 mg) according to the procedure described in Example 14. LC-MS: tR=5.22; [M+H]+=606.75.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07094781B2
출처 데이터셋uspto-grants-2006_08
ORD IDord-0557e87742a0462f9f27941c55dcda0f
출처 메모uspto-grants-2006_08