Dichloroacetic Acid → HCID 60133556, 화합물

HRID 1026721노트

반응식

HRID 1026721 반응식
[O:1]1[C:5]2([CH2:10][CH2:9][N:8]([C:11]3[CH:16]=[CH:15][C:14]([N:17]4[CH2:21][C@H:20]([CH2:22][NH2:23])[O:19][C:18]4=[O:24])=[CH:13][C:12]=3[F:25])[CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.[Cl:26][CH:27]([Cl:31])[C:28](O)=[O:29].C1(N=C=NC2CCCCC2)CCCCC1>ClCCl>[O:1]1[C:5]2([CH2:6][CH2:7][N:8]([C:11]3[CH:16]=[CH:15][C:14]([N:17]4[CH2:21][C@H:20]([CH2:22][NH:23][C:28](=[O:29])[CH:27]([Cl:31])[Cl:26])[O:19][C:18]4=[O:24])=[CH:13][C:12]=3[F:25])[CH2:9][CH2:10]2)[O:4][CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 6597Dichloroacetic AcidHCID 10868DicyclohexylcarbodiimideHCID 60133549HCID 60133549, 화합물

생성물 1

HCID 60133556HCID 60133556, 화합물수율 52%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The title compound was prepared by reacting (S)—N-{3-[4-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-amine (0.2 mmol, Example H) with dichloroacetic acid (2.1 mmol), dicyclohexylcarbodimide (2.1 mmol) in dichloromethane (10 ml) at a temperature 0-25° C. for 3 hours followed by silica gel column chromatographic purification in 52% yield.

후처리

  1. customat a temperature 0-25° C.
  2. customfor 3 hours
  3. customfollowed by silica gel column chromatographic purification in 52% yield

출처 및 근거

ORD 기록
ord-a7f085f801914b11bc4b765971ac5317
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08729269B2

반응 노트

불러오는 중…