2-Fluoro-3-methylaniline → HCID 67539869, 화합물

HRID 1026965

반응식

HRID 1026965 반응식
Cl[C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:6]2[N:5]=[CH:4][C:3]=1[C:16]([N:18]1[CH2:23][CH2:22][CH:21]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:20][CH2:19]1)=[O:17].[F:30][C:31]1[C:37]([CH3:38])=[CH:36][CH:35]=[CH:34][C:32]=1[NH2:33]>>[CH2:14]([O:13][C:11]([C:10]1[CH:9]=[N:8][N:7]2[C:2]([NH:33][C:32]3[CH:34]=[CH:35][CH:36]=[C:37]([CH3:38])[C:31]=3[F:30])=[C:3]([C:16]([N:18]3[CH2:23][CH2:22][CH:21]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[CH2:20][CH2:19]3)=[O:17])[CH:4]=[N:5][C:6]=12)=[O:12])[CH3:15]

참가 물질

3

반응물 2

HCID 227346232-Fluoro-3-methylanilineHCID 866462907-Chloro-3-ethoxycarbonyl-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine

생성물 1

HCID 67539869HCID 67539869, 화합물수율 99.7%

실험 절차

In the same manner as in Example 19, step 5 and using 7-chloro-3-ethoxycarbonyl-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine (100 mg, 0.24 mmol) obtained in Example 19, step 4 and 2-fluoro-3-methylaniline (46 mg, 0.36 mmol), the title compound (120 mg, 99%) was obtained.

출처 및 근거

ORD 기록
ord-3087c2c910614341a6e4b06295b60ebb
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08729264B2

연결된 노트

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