Potassium tert-butoxide → 3-((6S)-6-((S)-1-(tert-butyldimethylsilyloxy)ethyl)-2,2-dimethylpiperidin-4-yloxy)-6-(2-methoxy-4-(1H-pyrazol-1-yl)phenyl)pyridazine

반응식

Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([N:14]3[CH:18]=[CH:17][CH:16]=[N:15]3)=[CH:10][C:9]=2[O:19][CH3:20])=[CH:6][CH:7]=1.[Si:21]([O:28][C@H:29]([C@H:31]1[NH:36][C:35]([CH3:38])([CH3:37])[CH2:34][CH:33]([OH:39])[CH2:32]1)[CH3:30])([C:24]([CH3:27])([CH3:26])[CH3:25])([CH3:23])[CH3:22].CC(C)([O-])C.[K+]>CN(C=O)C>[Si:21]([O:28][C@H:29]([C@H:31]1[NH:36][C:35]([CH3:38])([CH3:37])[CH2:34][CH:33]([O:39][C:2]2[N:3]=[N:4][C:5]([C:8]3[CH:13]=[CH:12][C:11]([N:14]4[CH:18]=[CH:17][CH:16]=[N:15]4)=[CH:10][C:9]=3[O:19][CH3:20])=[CH:6][CH:7]=2)[CH2:32]1)[CH3:30])([C:24]([CH3:27])([CH3:25])[CH3:26])([CH3:23])[CH3:22]