Ethyl 4-piperidinecarboxylate → HCID 60658779, 화합물

HRID 1028107노트

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HRID 1028107 반응식
Br[C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[NH:7]1[CH2:12][CH2:11][CH:10]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:9][CH2:8]1>ClCCl>[S:3]1[CH:4]=[CH:5][N:6]=[C:2]1[N:7]1[CH2:12][CH2:11][CH:10]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:9][CH2:8]1

참가 물질

4

반응물 2

HCID 70770Ethyl 4-piperidinecarboxylateHCID 764302-Bromothiazole

생성물 1

HCID 60658779HCID 60658779, 화합물수율 86%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

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온도
100 °C

실험 절차

A mixture of 2-bromo-1,3-thiazole (522 mg, 3.18 mmol) and ethyl piperidine-4-carboxylate (1 g, 6.36 mmol) was heated to 100° C. neat overnight, then cooled to room temperature. The residue was dissolved in dichloromethane and directly purified by CombiFlash (0-40% ethyl acetate/hexanes) to provide 654 mg (2.7 2 mmol, 86% yield) of ethyl 1-(1,3-thiazol-2-yl)piperidine-4-carboxylate as a colorless oil.

후처리

  1. temperaturecooled to room temperature
  2. customdirectly purified by CombiFlash (0-40% ethyl acetate/hexanes)

출처 및 근거

ORD 기록
ord-2b8376797d6646048f64e645b450f059
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08735417B2

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