Bromine → HCID 67458099, 화합물

HRID 1028108노트

반응식

HRID 1028108 반응식
[Br:1]Br.[S:3]1[CH:7]=[CH:6][N:5]=[C:4]1[N:8]1[CH2:13][CH2:12][CH:11]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:10][CH2:9]1>C(O)(=O)C.C(OCC)(=O)C>[Br:1][C:7]1[S:3][C:4]([N:8]2[CH2:13][CH2:12][CH:11]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:10][CH2:9]2)=[N:5][CH:6]=1

참가 물질

5

반응물 2

HCID 24408BromineHCID 60658779HCID 60658779, 화합물

생성물 1

HCID 67458099HCID 67458099, 화합물수율 97.4%

시약·촉매·용매 2

HCID 176Acetic Acid용매2회HCID 8857Ethyl Acetate용매

실험 절차

Bromine (0.14 mL, 2.7 mmol) was weighed into a vial and then diluted with acetic acid (1 mL). This solution was added dropwise (over 10 minutes) to a solution of ethyl 1-(1,3-thiazol-2-yl)piperidine-4-carboxylate (650 mg, 2.7 mmol) in acetic acid (12.5 mL). The mixture was then diluted with ethyl acetate (100 mL) and washed with water (100 mL) and brine (100 mL). The organic layer was dried over sodium sulfate and concentrated in vacuo to provide 840 mg (2.63 mmol, 97% yield) of ethyl 1-(5-bromo-1,3-thiazol-2-yl)piperidine-4-carboxylate as a green oil.

후처리

  1. washwashed with water (100 mL) and brine (100 mL)
  2. dry with materialThe organic layer was dried over sodium sulfate
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-b430eadc81f14116948713a96529db0e
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08735417B2

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