Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(2,3-Dimethylphenyl)(1-trityl-1H-imidazol-5-yl)methanone → 1-(2,3-Dimethylphenyl)-2-phenyl-1-(1-trityl-1h-imidazol-5-yl)ethanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (2,3-Dimethylphenyl)(1-trityl-1H-imidazol-5-yl)methanone | HCID 42631463 | — |
| 반응물 | HCID 178419663 | HCID 178419663 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-(2,3-Dimethylphenyl)-2-phenyl-1-(1-trityl-1h-imidazol-5-yl)ethanol | HCID 57437678 | — |
반응 단계
A solution of (2,3-dimethylphenyl)(I-trityl-1H imidazol-5-yl)methanone (450 mg, 1.01 mmol) in dichloromethane (25 mL) at room temperature was treated with benzyl magnesium bromide (1.51 mmol) and allowed to react at room temperature and the reaction mixture was then stirred at room temperature for 5 hours. The mixture was quenched with water (10 mL) and a sat. solution of ammonium chloride (10 mL). The residue was isolated in a typical aqueous to give 1-(2,3-dimethylphenyl)-2-phenyl-1-(1-trityl-1H-imidazol-5-yl)ethanol (Intermediate 8) crude, which was taken to the next step without any purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08735438B2 |
| 출처 데이터셋 | uspto-grants-2014_05 |
| ORD ID | ord-6ef30ff6861c404196202d8c13e54eb8 |
| 출처 메모 | uspto-grants-2014_05 |