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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1028192생성일: 2026년 10월 26일

(2,3-Dimethylphenyl)(1-trityl-1H-imidazol-5-yl)methanone → 1-(2,3-Dimethylphenyl)-2-phenyl-1-(1-trityl-1h-imidazol-5-yl)ethanol

https://huagongshe.com/reaction/1028192

반응식

참여 물질

역할이름HCID투입량
반응물(2,3-Dimethylphenyl)(1-trityl-1H-imidazol-5-yl)methanoneHCID 42631463—
반응물HCID 178419663HCID 178419663—
용매DichloromethaneHCID 6344—
생성물1-(2,3-Dimethylphenyl)-2-phenyl-1-(1-trityl-1h-imidazol-5-yl)ethanolHCID 57437678—

반응 단계

A solution of (2,3-dimethylphenyl)(I-trityl-1H imidazol-5-yl)methanone (450 mg, 1.01 mmol) in dichloromethane (25 mL) at room temperature was treated with benzyl magnesium bromide (1.51 mmol) and allowed to react at room temperature and the reaction mixture was then stirred at room temperature for 5 hours. The mixture was quenched with water (10 mL) and a sat. solution of ammonium chloride (10 mL). The residue was isolated in a typical aqueous to give 1-(2,3-dimethylphenyl)-2-phenyl-1-(1-trityl-1H-imidazol-5-yl)ethanol (Intermediate 8) crude, which was taken to the next step without any purification.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08735438B2
출처 데이터셋uspto-grants-2014_05
ORD IDord-6ef30ff6861c404196202d8c13e54eb8
출처 메모uspto-grants-2014_05