Sulfuric Acid → 3-[Ethyl(hydroxy)phosphoryl]propanoic acid
반응식
[Na+].[CH2:2]([P:4]([OH:11])([CH2:6][CH2:7][C:8]([O-:10])=[O:9])=[O:5])[CH3:3].S(=O)(=O)(O)O>O>[CH2:2]([P:4]([OH:11])([CH2:6][CH2:7][C:8]([OH:10])=[O:9])=[O:5])[CH3:3]참가 물질
4
실험 절차
630 g (3 mol) of 3-(ethylhydroxyphosphinyl)propionic acid sodium salt (produced as in Example 16) are dissolved in 860 g of water and initially charged into a 5 l five-neck flask equipped with thermometer, reflux condenser, high-performance stirrer and dropping funnel and neutralized by addition of about 147 g (1.5 mol) of concentrated sulfuric acid. The water is subsequently distilled off in vacuo. The residue is taken up in ethanol and the insoluble salts are filtered off. The solvent of the filtrate is removed in vacuo to leave 488 g (98% of theory) of 3-(ethylhydroxy-phosphinyl)propionic acid as a solid material.
후처리
- additioninitially charged into a 5 l five-neck flask
- customequipped with thermometer
- temperaturereflux condenser, high-performance stirrer
- distillationThe water is subsequently distilled off in vacuo
- filtrationthe insoluble salts are filtered off
- customThe solvent of the filtrate is removed in vacuo
출처 및 근거
- ORD 기록
- ord-e8275dfa450d4b34a6186bb1fe055b14
- 출처 데이터셋
- uspto-grants-2014_05
- 특허 번호
- US08735477B2
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