Acetanilide → 2,4-Dimethyl-1-phenyl-1H-benzimidazole

HRID 1028377

반응식

HRID 1028377 반응식
Br[C:2]1[C:3]([N+:9]([O-])=O)=[C:4]([CH3:8])[CH:5]=[CH:6][CH:7]=1.[C:12]1([NH:18][C:19](=O)[CH3:20])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[CH3:20][C:19]1[N:18]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:2]2[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=2[N:9]=1

참가 물질

3

반응물 2

HCID 904AcetanilideHCID 142929Benzene, 1-bromo-3-methyl-2-nitro-

생성물 1

HCID 248214482,4-Dimethyl-1-phenyl-1H-benzimidazole수율 33.3%

실험 절차

The title compound was prepared with the analogous procedure described in example 1 using 3-Bromo-2-nitrotoluene (108 mg, 0.5 mmol) and N-phenylacetamide (81 mg, 0.6 mmol), as starting materials to yield the title compound as brown solid (37 mg, 33%). 1H NMR (DMSO) δ 2.46 (s, 3 H), 2.55 (s, 3 H), 6.88 (d, J=7.3 Hz, 1 H), 7.04-7.11 (m, 2 H), 7.50-7.64 (m, 5 H); 13C NMR δ 13.8, 16.3, 107.5, 122.5, 122.6, 126.8, 129.9, 135.1, 135.3, 150.3, 158.3.

후처리

  1. customThe title compound was prepared with the analogous procedure

출처 및 근거

ORD 기록
ord-b192cc86c3c04b70b84abb50f15ccc98
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08735586B2

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