홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

3-benzyloxy-N-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-4-methyl-benzamide → N-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-3-hydroxy-4-methyl-benzamide

HRID 1028424
노트
인쇄 미리보기

반응식

HRID 1028424 반응식
C([O:8][C:9]1[CH:10]=[C:11]([CH:32]=[CH:33][C:34]=1[CH3:35])[C:12]([NH:14][C:15]1[CH:20]=[C:19]([C:21]([CH3:24])([CH3:23])[CH3:22])[CH:18]=[C:17]([NH:25][S:26]([CH3:29])(=[O:28])=[O:27])[C:16]=1[O:30][CH3:31])=[O:13])C1C=CC=CC=1.[H][H]>CO.O1CCCC1.[Pd]>[C:21]([C:19]1[CH:18]=[C:17]([NH:25][S:26]([CH3:29])(=[O:28])=[O:27])[C:16]([O:30][CH3:31])=[C:15]([NH:14][C:12](=[O:13])[C:11]2[CH:32]=[CH:33][C:34]([CH3:35])=[C:9]([OH:8])[CH:10]=2)[CH:20]=1)([CH3:24])([CH3:22])[CH3:23]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 2

HCID 672175483-benzyloxy-N-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-4-methyl-benzamideHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 67217566N-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-3-hydroxy-4-methyl-benzamide

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 887Methanol용매
HCID 8028
Tetrahydrofuran
용매

실험 절차

7.10 g 3-benzyloxy-N-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-4-methyl-benzamide are hydrogenated in a mixture of 70 ml of methanol and 40 ml of tetrahydrofuran in the presence of 800 mg palladium on activated charcoal (10% Pd) at ambient temperature and 50 psi partial hydrogen pressure. Then the catalyst is suction filtered and the filtrate is evaporated down using the rotary evaporator. A white solid remains, which is reacted further without any further purification.

후처리

  1. filtrationfiltered
  2. customthe filtrate is evaporated down
  3. customthe rotary evaporator
  4. customA white solid remains, which is reacted further without any further purification

출처 및 근거

ORD 기록
ord-15404f0639c14a02a2af7a618b06b3d4
출처 데이터셋
uspto-grants-2014_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08735579B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트