Water → 3-(Benzyloxy)-4-chlorobenzoic acid

HRID 1028428

반응식

HRID 1028428 반응식
[CH2:1](Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:9][C:10]1[CH:11]=[C:12]([CH:16]=[CH:17][C:18]=1[Cl:19])[C:13]([OH:15])=[O:14].C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[CH2:1]([O:9][C:10]1[CH:11]=[C:12]([CH:16]=[CH:17][C:18]=1[Cl:19])[C:13]([OH:15])=[O:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 1418724-Chloro-3-hydroxybenzoic acid

생성물 1

HCID 672169913-(Benzyloxy)-4-chlorobenzoic acid

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

2.67 ml benzylbromide are added dropwise to 1.73 g 3-hydroxy-4-chloro-benzoic acid and 3.04 g potassium carbonate in 10 ml N,N-dimethylformamide, and the reaction mixture is stirred overnight at ambient temperature. Then the reaction mixture is mixed with water and extracted with ethyl acetate. The combined organic phases are dried on magnesium sulphate and evaporated down. The flask residue is taken up in 5 ml of methanol, combined with 3 ml of 10 M aqueous potassium hydroxide solution and stirred for 4 h at 50° C. gerũhrt. The reddish solution is diluted with water and acidified with 3 N aqueous hydrochloric acid. The precipitate formed is suction filtered, washed with water and dried.

후처리

  1. extractionextracted with ethyl acetate
  2. customThe combined organic phases are dried on magnesium sulphate
  3. customevaporated down
  4. stirringstirred for 4 h at 50° C. gerũhrt
  5. additionThe reddish solution is diluted with water
  6. customThe precipitate formed
  7. filtrationfiltered
  8. washwashed with water
  9. customdried

출처 및 근거

ORD 기록
ord-b482f705a77e45a48813b6dd73e82284
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08735579B2

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