4-Methoxybenzylamine → 6-bromo-3-iodo-N-(4-methoxybenzyl)quinolin-2-amine

HRID 1028933노트

반응식

HRID 1028933 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7](Cl)[C:6]([I:13])=[CH:5]2.[CH3:14][O:15][C:16]1[CH:23]=[CH:22][C:19]([CH2:20][NH2:21])=[CH:18][CH:17]=1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:21][CH2:20][C:19]1[CH:22]=[CH:23][C:16]([O:15][CH3:14])=[CH:17][CH:18]=1)[C:6]([I:13])=[CH:5]2

참가 물질

3

반응물 2

HCID 754524-MethoxybenzylamineHCID 866768376-Bromo-2-chloro-3-iodoquinoline

생성물 1

HCID 673456526-bromo-3-iodo-N-(4-methoxybenzyl)quinolin-2-amine

반응 조건

온도
130 °C

실험 절차

6-Bromo-2-chloro-3-iodoquinoline (1.0 g, 2.7 mmol) and neat 4-methoxybenzylamine (3.6 mL, 27.1 mmol) was combined in a microwave vial and heated in a microwave at 130° C. for 15 min. The reaction mixture was purified by silica flash chromatography (0-30% EtOAc/Hex) to give 6-bromo-3-iodo-N-(4-methoxybenzyl)quinolin-2-amine as a yellow solid.

후처리

  1. customThe reaction mixture was purified by silica flash chromatography (0-30% EtOAc/Hex)

출처 및 근거

ORD 기록
ord-eced43b58d884e6baa1a3d853801dd21
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08735384B2

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