Water → 6-bromo-3-iodo-N-(4-methoxybenzyl)quinolin-2-amine

HRID 1028989노트

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HRID 1028989 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7](Cl)[C:6]([I:13])=[CH:5]2.[CH3:14][O:15][C:16]1[CH:23]=[CH:22][C:19]([CH2:20][NH2:21])=[CH:18][CH:17]=1.O>CN1CCCC1=O>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:21][CH2:20][C:19]1[CH:22]=[CH:23][C:16]([O:15][CH3:14])=[CH:17][CH:18]=1)[C:6]([I:13])=[CH:5]2

참가 물질

5

반응물 3

HCID 962WaterHCID 754524-MethoxybenzylamineHCID 866768376-Bromo-2-chloro-3-iodoquinoline

생성물 1

HCID 673456526-bromo-3-iodo-N-(4-methoxybenzyl)quinolin-2-amine

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

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온도
130 °C

실험 절차

A glass microwave reaction vessel was charged with 6-bromo-2-chloro-3-iodoquinoline (0.918 g, 2.492 mmol) and 4-methoxybenzylamine (2.279 mL, 17.44 mmol) in N-methyl-2-pyrrolidinone (3.56 mL). The reaction mixture was stirred and heated in a microwave reactor at 130° C. for 20 min. The solution was poured into water and extracted with diethyl ether. The combined organic extracts were washed with saturated ammonium chloride, water, saturated sodium chloride, and dried over magnesium sulfate. The solution was filtered and concentrated in vacuo to give the crude material 6-bromo-3-iodo-N-(4-methoxybenzyl)quinolin-2-amine as a tan solid which was used without further purification.

후처리

  1. customA glass microwave reaction vessel
  2. extractionextracted with diethyl ether
  3. washThe combined organic extracts were washed with saturated ammonium chloride, water, saturated sodium chloride
  4. dry with materialdried over magnesium sulfate
  5. filtrationThe solution was filtered
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-52f3dfeb604f4fb4ad89172184062663
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08735384B2

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