Cyclohexanone, 2-(hydroxymethylene)- → HCID 71253453, 화합물

HRID 1029003

반응식

HRID 1029003 반응식
Cl.[Br:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][NH2:10].O[CH:12]=[C:13]1[CH2:18][CH2:17][CH2:16][CH2:15][C:14]1=O>C(O)C>[Br:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[C:14]2[CH2:15][CH2:16][CH2:17][CH2:18][C:13]=2[CH:12]=[N:10]1

참가 물질

4

반응물 2

HCID 101871Cyclohexanone, 2-(hydroxymethylene)-HCID 27239122-Bromophenylhydrazine hydrochloride

생성물 1

HCID 71253453HCID 71253453, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2-Bromophenylhydrazine hydrochloride (1.00 g, 4.47 mmol) was added to a solution of 2-(hydroxymethylene)cyclohexanone (0.564 g, 4.47 mmol) in ethanol (20 mL) and the resulting solution was refluxed 3 h before being concentrated. The crude material was taken up in DCM and washed with saturated ammonium chloride, 1N NaOH, saturated sodium chloride, and dried over sodium sulfate. The solution was filtered and concentrated in vacuo to give 1-(2-bromophenyl)-4,5,6,7-tetrahydro-1H-indazole.

후처리

  1. temperaturethe resulting solution was refluxed 3 h
  2. concentrationbefore being concentrated
  3. washwashed with saturated ammonium chloride, 1N NaOH, saturated sodium chloride
  4. dry with materialdried over sodium sulfate
  5. filtrationThe solution was filtered
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-533b0c10b45c4331af854929507f2e56
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08735384B2

연결된 노트

불러오는 중…