Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → 2,5-Dichloro-N-[4-(6-oxo-5,6-dihydro-benzo[c][1,8]naphthyridin-1-yloxy)-phenyl]-nicotinamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 2,5-Dichloro-nicotinoyl chloride | HCID 2799996 | — |
| 반응물 | 1-(4-Amino-phenoxy)-5H-benzo[c][1,8]naphthyridin-6-one | HCID 58168367 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 용매 | Water ethylacetate | HCID 22728543 | — |
| 생성물 | 2,5-Dichloro-N-[4-(6-oxo-5,6-dihydro-benzo[c][1,8]naphthyridin-1-yloxy)-phenyl]-nicotinamide | HCID 58168327 | 64.5% |
반응 단계
Compound 137 (40 mg, 0.13 mmol), 2,5-dichloro-nicotinoyl chloride (28 mg, 0.13 mmol), and DIEA (0.02 mL, 0.13 mmol) were suspended in dioxane (2 mL), and stirred overnight at room temperature. The reaction mixture was diluted with EtOAc/H2O. The resulting precipitate was filtered, washed with EtOAc/H2O, and dried under vacuum to provide 180 (40 mg, 64% yield) as a white solid. LC-MS (M+H=478, obsd.=478).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08735584B2 |
| 출처 데이터셋 | uspto-grants-2014_05 |
| ORD ID | ord-6086b94094634432a2e6dc0c1eea5f42 |
| 출처 메모 | uspto-grants-2014_05 |