Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,2-Difluoro-1,3-dioxaindan-4-amine → 1-(2,2-Difluoro-benzo[1,3]-dioxol-4-ylamino)-5H-benzo[c][1,8]naphthyridin-6-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,2-Difluoro-1,3-dioxaindan-4-amine | HCID 2736891 | — |
| 반응물 | 1-Chlorobenzo[C][1,8]naphthyridin-6(5H)-one | HCID 58168008 | — |
| 생성물 | 1-(2,2-Difluoro-benzo[1,3]-dioxol-4-ylamino)-5H-benzo[c][1,8]naphthyridin-6-one | HCID 58168192 | 77.2% |
반응 단계
The title compound was synthesized according to the procedure described for the preparation of Example 188 using Compound 83 (100 mg, 0.43 mmol) and 2,2-difluoro-benzo[1,3]dioxol-4-ylamine (150 mg, 0.87 mmol) to provide 196 (122 mg, 77% yield) as a white solid. LC-MS (M+H=368, obsd.=368).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08735584B2 |
| 출처 데이터셋 | uspto-grants-2014_05 |
| ORD ID | ord-9298ac35552149928b82e794018741d1 |
| 출처 메모 | uspto-grants-2014_05 |