Hydrochloric Acid → Methyl 1-(4-benzamidophenylamino)-6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridine-8-carboxylate

참여 물질

역할	이름	HCID	투입량
반응물	Hydrochloric Acid	HCID 313	—
반응물	Benzamide, N-(4-aminophenyl)-	HCID 87196	—
반응물	Methyl 1-chloro-6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridine-8-carboxylate	HCID 58168369	—
용매	Water	HCID 962	—
용매	N-methyl-2-pyrrolidone	HCID 13387	—
생성물	Methyl 1-(4-benzamidophenylamino)-6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridine-8-carboxylate	HCID 44205292	96%

반응 조건

온도	115 °C

반응 단계

266 (250 mg, 0.77 mol), N-(4-aminophenyl)benzamide (179 mg, 0.85 mmol), and HCl (19 μm, 0.77 mmol, 4.0 M in dioxane) were suspended in NMP (5 mL) and stirred for 30 h at 115° C. The reaction mixture was diluted with H2O. The resulting precipitate was filtered, washed with H2O and MeOH, and dried under vacuum to provide 267 (341 mg, 96% yield) as a white solid. LC-MS (M+H=465, obsd.=465).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08735584B2
출처 데이터셋	uspto-grants-2014_05
ORD ID	ord-00a38f894260489c8c0ddaaace553e8a
출처 메모	uspto-grants-2014_05