2-(Bromomethyl)-1-fluoro-3-(trifluoromethyl)benzene → HCID 58168173, 화합물

HRID 1029282

반응식

HRID 1029282 반응식
[NH2:1][C:2]1[CH:16]=[CH:15][C:5]2[C:6](=[O:14])[NH:7][C:8]3[C:13]([C:4]=2[CH:3]=1)=[CH:12][CH:11]=[CH:10][N:9]=3.Br[CH2:18][C:19]1[C:24]([C:25]([F:28])([F:27])[F:26])=[CH:23][CH:22]=[CH:21][C:20]=1[F:29]>>[F:29][C:20]1[CH:21]=[CH:22][CH:23]=[C:24]([C:25]([F:26])([F:27])[F:28])[C:19]=1[CH2:18][NH:1][C:2]1[CH:16]=[CH:15][C:5]2[C:6](=[O:14])[NH:7][C:8]3[C:13]([C:4]=2[CH:3]=1)=[CH:12][CH:11]=[CH:10][N:9]=3

참가 물질

3

반응물 2

HCID 27375732-(Bromomethyl)-1-fluoro-3-(trifluoromethyl)benzeneHCID 58167951HCID 58167951, 화합물

생성물 1

HCID 58168173HCID 58168173, 화합물수율 5.3%

실험 절차

The title compound was synthesized according to the procedure described for the preparation of Example 458 using 70 (122 mg, 0.58 mmol) and 2-(bromomethyl)-1-fluoro-3-(trifluoromethyl)benzene (179 mg, 0.70 mmol) to provide 461 (12 mg, 5% yield) as a white powder. LC-MS (M+H=388, obsd.=388). 1H NMR (400 MHz, DMSO-D6) δ 8.53 (dd, J=1.7, 8.0, 1H), 8.43 (dd, J=1.6, 4.7, 1H), 8.00 (d, J=8.7, 1H), 7.95 (s, 1H), 7.63 (d, J=7.8, 1H), 7.46 (dd, J=8.1, 13.2, 1H), 7.40 (d, J=2.1, 1H), 7.32 (dd, J=4.7, 7.9, 2H), 6.88 (dd, J=2.0, 8.7, 1H), 6.20 (s, 2H), 5.90 (s, 1H).

후처리

  1. customThe title compound was synthesized

출처 및 근거

ORD 기록
ord-5dfb5a0e58b547a28c41d1b71b9c6beb
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08735584B2

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