Triethylamine → 4-[3-Ethylbenzothiazolinylidene]-3-methyl-1-phenylpyrazolin-5-one

HRID 1029363

반응식

HRID 1029363 반응식
[CH3:1][C:2]1[NH:3][N:4]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:5](=[O:7])[CH:6]=1.S(C1C=CC(C)=CC=1)([O-])(=O)=O.C(S[C:28]1[S:29][C:30]2[CH:38]=[CH:37][CH:36]=[CH:35][C:31]=2[N+:32]=1[CH2:33][CH3:34])C.C(N(CC)CC)C>CO>[CH2:33]([N:32]1[C:31]2[CH:35]=[CH:36][CH:37]=[CH:38][C:30]=2[S:29](=[C:6]2[C:5](=[O:7])[N:4]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)[NH:3][CH:2]2[CH3:1])[CH2:28]1)[CH3:34]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 703351H-Pyrazol-5-ol, 3-methyl-1-phenyl-HCID 140905473-Ethyl-2-(ethylsulfanyl)-1,3-benzothiazol-3-ium 4-methylbenzene-1-sulfonate

생성물 1

HCID 867456164-[3-Ethylbenzothiazolinylidene]-3-methyl-1-phenylpyrazolin-5-one

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

3-Methyl-1-phenylpyrazolin-5-one (1.74 g, 0.01 mol) was mixed with a methanol solution of 2-ethylthio-3-ethylbenzothiazolium tosylate. Triethylamine (1.01 g, 0.01 mol) was added. The mixture was stirred for 10 minutes, then concentrated and treated with isopropanol. The mixture was heated to dissolve the product, then water was added to cloud, and the mixture cooled to give crystals: 3.22 g (48%), mp 144°-147.5° C., λmax=379 (ε=25,000).

후처리

  1. concentrationconcentrated
  2. additiontreated with isopropanol
  3. temperatureThe mixture was heated
  4. dissolutionto dissolve the product
  5. additionwater was added to cloud
  6. temperaturethe mixture cooled
  7. customto give crystals

출처 및 근거

ORD 기록
ord-b931c63ecf554f069f4279a9ac934fab
출처 데이터셋
uspto-grants-1992_04
특허 번호
US05102781

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