3,3,3-Trifluoropropyl-trimethoxysilane → 3,3,3-Trifluoropropyl(cyclopentyl)dimethoxysilane

HRID 1029379

반응식

HRID 1029379 반응식
[CH:1]1([Mg]Cl)[CH2:5][CH2:4][CH2:3][CH2:2]1.[F:8][C:9]([F:20])([F:19])[CH2:10][CH2:11][Si:12](OC)([O:15][CH3:16])[O:13][CH3:14].[SiH4].CCCCCC>C(OCC)C.CCCCCC>[F:20][C:9]([F:8])([F:19])[CH2:10][CH2:11][Si:12]([CH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1)([O:13][CH3:14])[O:15][CH3:16]

참가 물질

6

반응물 3

HCID 679333,3,3-Trifluoropropyl-trimethoxysilaneHCID 131717238Silane hexaneHCID 178478989HCID 178478989, 화합물

생성물 1

HCID 199000453,3,3-Trifluoropropyl(cyclopentyl)dimethoxysilane

시약·촉매·용매 2

HCID 3283Diethyl Ether용매2회HCID 8058Hexane용매

실험 절차

Under nitrogen, a 500 ml Schlenk flask was cooled to room temperature, charged with 150 ml of diethyl ether and cyclopentylmagnesium chloride (0.055 mol, 27.7 ml) and warmed slightly to 30° C. A 100 ml Schlenk flask was purged with nitrogen and charged with 75 ml hexane and 3,3,3-trifluoropropyltrimethoxy silane (10 ml, 0.0504 mol). The silane/hexane solution was added dropwise via cannula to the Grignard/diethyl ether mixture producing a white cloudy mixture. After addition (1.25 hrs.), the Grignard containing flask was rinsed once with 25 ml of hexane. The reaction mixture was stirred at room temperature for one hour.

후처리

  1. temperaturewarmed slightly to 30° C
  2. customA 100 ml Schlenk flask was purged with nitrogen
  3. customproducing a white cloudy mixture
  4. additionAfter addition (1.25 hrs.)
  5. additionthe Grignard containing flask
  6. washwas rinsed once with 25 ml of hexane

출처 및 근거

ORD 기록
ord-dc2a1dd5867444178c2fa5cf1148e5a1
출처 데이터셋
uspto-grants-1992_04
특허 번호
US05102842

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