Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Bromophenol → Silane, (4-bromophenoxy)(1,1-dimethylethyl)diphenyl-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Bromophenol | HCID 7808 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | tert-Butyldiphenylchlorosilane | HCID 94078 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Silane, (4-bromophenoxy)(1,1-dimethylethyl)diphenyl- | HCID 11292808 | — |
반응 단계
To a solution of 4-bromophenol (16.4 g, 0.1 mole) in CH2Cl2 (300 mL) was added t-butyldiphenylsilyl chloride (29 g, 0.1 mole), Et3N (20 g, 0.2 mole) and 4-dimethylaminopyridine (DMAP) (1 g). The solution was stirred at RT for 2 days, quenched with H2O (1 L) and extracted with ether (2 L). The ether extracts were dried and evaporated. Flash chromatography of the residue using 5% ethyl acetate in hexane afforded the title compound which was used as such for the next step.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05102881 |
| 출처 데이터셋 | uspto-grants-1992_04 |
| ORD ID | ord-a0a3602cbbce4042ab71be1cd02e2f2a |
| 출처 메모 | uspto-grants-1992_04 |