Acetic Acid → 4-(4-(4-Chlorophenyl)-1-hydroxybutyl)phenol

HRID 1029458노트

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HRID 1029458 반응식
[F-].C([N+](CCCC)(CCCC)CCCC)CCC.CC([Si](C1C=CC=CC=1)(C1C=CC=CC=1)[O:24][C:25]1[CH:30]=[CH:29][C:28]([CH:31]([OH:42])[CH2:32][CH2:33][CH2:34][C:35]2[CH:40]=[CH:39][C:38]([Cl:41])=[CH:37][CH:36]=2)=[CH:27][CH:26]=1)(C)C.CC(O)=O>C1COCC1>[Cl:41][C:38]1[CH:39]=[CH:40][C:35]([CH2:34][CH2:33][CH2:32][CH:31]([C:28]2[CH:27]=[CH:26][C:25]([OH:24])=[CH:30][CH:29]=2)[OH:42])=[CH:36][CH:37]=1

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 2724141Tetrabutylammonium FluorideHCID 538578064-(4-Chlorophenyl)-1-(4-t-butyldiphenylsiloxy phenyl)butanol

생성물 1

HCID 197458724-(4-(4-Chlorophenyl)-1-hydroxybutyl)phenol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

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온도
0 °C

실험 절차

At 0° C., 1M tetrabutylammonium fluoride (100 mL) was added to a solution of the silyl ether of Step 2 (34 g) and AcOH (15 mL) in THF (200 mL) and the reaction mixture was stirred at 0° C. 2.5 hours. 25% aqueous NH4OAc was then added and the product was extracted with EtOAc, dried over MgSO4 and purified by a swish in EtOAc:hexane 1:2. The title compound so obtained was used as such for the next step.

후처리

  1. custom2.5 hours
  2. extractionthe product was extracted with EtOAc
  3. dry with materialdried over MgSO4
  4. custompurified by a swish in EtOAc:hexane 1:2

출처 및 근거

ORD 기록
ord-0ee4c7c503264db9b78d8cbc8f77b9a5
출처 데이터셋
uspto-grants-1992_04
특허 번호
US05102881

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