Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Methylhexanoyl chloride → 2-(7-Methyl-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl 5-methylhexanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Methylhexanoyl chloride | HCID 13664865 | — |
| 반응물 | 2-(7-Methyl-1,8-naphthyridin-2-yl)-3-hydroxy-1-isoindolinone | HCID 19900439 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | 2-(7-Methyl-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl 5-methylhexanoate | HCID 70057156 | 74.2% |
반응 단계
The procedure is as in example 7, but starting with 2-(7-methyl-1,8-naphthyridin-2-yl)-3-hydroxy-1-isoindolinone (3.7 g), 5-methylhexanoyl chloride (7.8 g), triethylamine (12 cc) and 4-diemthylaminopyridine (50 mg). After the solid obtained after treatment has been recrystallized in methylcyclohexane, 2-(7-methyl-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl 5-methylhexanoate (3.8 g), m.p. 144° C., is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05102890 |
| 출처 데이터셋 | uspto-grants-1992_04 |
| ORD ID | ord-1c52e89755fa4372a03b57242696e688 |
| 출처 메모 | uspto-grants-1992_04 |