3-chloro-4-(trifluoromethoxy)benzamide → 3-chloro-4-(trifluoromethoxy)benzonitrile

HRID 1030090노트

반응식

HRID 1030090 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][C:12]([F:15])([F:14])[F:13])[C:5]([NH2:7])=O>O=S(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][C:12]([F:13])([F:14])[F:15])[C:5]#[N:7]

참가 물질

3

반응물 1

HCID 27738443-chloro-4-(trifluoromethoxy)benzamide

생성물 1

HCID 27738463-chloro-4-(trifluoromethoxy)benzonitrile수율 85%

시약·촉매·용매 1

HCID 24386Thionyl Chloride용매

반응 조건

온도
85 °C

실험 절차

750 ml of SOCl2 were added to 239.5 g (1 mol) of 3-chloro-4-trifluoromethoxybenzamide and the mixture was heated slowly (corresponding to the evolution of gas) to 85° C. The mixture was then fractionally distilled and 189 g of product having a boiling point at 13 mbar of 96° C. and a melting point of 38° to 40° C. were obtained. This corresponds to a yield of 85% of theory.

후처리

  1. distillationThe mixture was then fractionally distilled
  2. customat 13 mbar of 96° C.
  3. customa melting point of 38° to 40° C. were obtained

출처 및 근거

ORD 기록
ord-ad79efa0e84b4743834490f2c901e2eb
출처 데이터셋
uspto-grants-1992_04
특허 번호
US05104879

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