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Acetone → 4-(1H-1,2,4-triazole-1-yl)-2,8-bis-trifluoromethyl-quinoline

HRID 1030103
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HRID 1030103 반응식
Cl[C:2]1[C:11]2[C:6](=[C:7]([C:12]([F:15])([F:14])[F:13])[CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([C:16]([F:19])([F:18])[F:17])[CH:3]=1.[NH:20]1[CH:24]=[N:23][CH:22]=[N:21]1.C(=O)([O-])[O-].[K+].[K+].CC(C)=O>O>[N:20]1([C:2]2[C:11]3[C:6](=[C:7]([C:12]([F:15])([F:14])[F:13])[CH:8]=[CH:9][CH:10]=3)[N:5]=[C:4]([C:16]([F:19])([F:18])[F:17])[CH:3]=2)[CH:24]=[N:23][CH:22]=[N:21]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 180AcetoneHCID 92571H-1,2,4-TriazoleHCID 11430Potassium CarbonateHCID 27332474-Chloro-2,8-bis(trifluoromethyl)quinoline

생성물 1

HCID 148378284-(1H-1,2,4-triazole-1-yl)-2,8-bis-trifluoromethyl-quinoline수율 73%

시약·촉매·용매 1

HCID 962
Water
용매

실험 절차

A mixture of 3.0 g of 4-chloro-2,8-bis-trifluoromethyl-quinoline, 1.38 g of 1,2,4-triazole, 1.38 g of potassium carbonate and 30 ml of acetone is heated to boiling for 23 hours whereupon the reaction mixture is poured into 100 ml of water. The precipitated product is filtered, dissolved in 5 ml of ethanol, whereupon 5 ml of water are added. The precipitated product is filtered. Thus 2.42 g of the desired compound are obtained, yield: 73%, mp.: 106°-107° C.

후처리

  1. temperatureis heated
  2. filtrationThe precipitated product is filtered
  3. dissolutiondissolved in 5 ml of ethanol, whereupon 5 ml of water
  4. additionare added
  5. filtrationThe precipitated product is filtered

출처 및 근거

ORD 기록
ord-31f5ee3a7d6b45f0b43928c251bbb6d3
출처 데이터셋
uspto-grants-1992_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05104884

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