Water → 2-(1H-1,2,4-triazole-1-yl)-3-methyl-quinoline

HRID 1030104노트

반응식

HRID 1030104 반응식
Cl[C:2]1[C:11]([CH3:12])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH:13]1[CH:17]=[N:16][CH:15]=[N:14]1.O.[OH-].[NH4+]>C(O)C>[N:13]1([C:2]2[C:11]([CH3:12])=[CH:10][C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=2)[CH:17]=[N:16][CH:15]=[N:14]1

참가 물질

6

반응물 4

HCID 962WaterHCID 92571H-1,2,4-TriazoleHCID 14923Ammonium HydroxideHCID 3390822-Chloro-3-methylquinoline

생성물 1

HCID 148378652-(1H-1,2,4-triazole-1-yl)-3-methyl-quinoline수율 71%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 1.78 g of 2-chloro-3-methyl-quinoline and 0.69 g of 1,2,4-triazole is melt and allowed to stand at 120° C. for 4 hours. The melt is cooled, then dissolved in 10 ml of ethanol, poured into 20 ml of water and neutralized with 1 ml of concentrated ammonium hydroxide. The precipitated product is filtered. Thus 1.49 g of the desired compound are obtained, yield 71%. Mp.: 80°-81° C.

후처리

  1. temperatureThe melt is cooled
  2. filtrationThe precipitated product is filtered

출처 및 근거

ORD 기록
ord-c6ec2a42594a4cdc9a89fcdd74a938f5
출처 데이터셋
uspto-grants-1992_04
특허 번호
US05104884

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