ethyl N-cyanopropionimidate → HCID 178457586, 화합물

HRID 1030218노트

반응식

HRID 1030218 반응식
[NH2:1][C@@H:2]1[C:7]2[CH:8]=[C:9]([C:12]#[N:13])[CH:10]=[CH:11][C:6]=2[O:5][C:4]([CH3:15])([CH3:14])[C@H:3]1[OH:16].[C:17]([N:19]=[C:20](OCC)[CH2:21][CH3:22])#[N:18]>C(O)C>[C:17]([N:19]=[C:20]([NH:1][C@@H:2]1[C:7]2[CH:8]=[C:9]([C:12]#[N:13])[CH:10]=[CH:11][C:6]=2[O:5][C:4]([CH3:14])([CH3:15])[C@H:3]1[OH:16])[CH2:21][CH3:22])#[N:18]

참가 물질

4

반응물 2

HCID 10820532ethyl N-cyanopropionimidateHCID 10943936(3S,4R)-4-amino-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile

생성물 1

HCID 178457586HCID 178457586, 화합물수율 47%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of trans-4-amino-3,4-dihydro-2,2-dimethyl-3-hydroxy-2H-1-benzopyran-6-carbonitrile (4.37 g) and ethyl N-cyanopropionimidate (2.65 g) in ethanol (22 ml) was refluxed for 10 hours. The mixture was cooled and concentrated under reduced pressure. The residue was pulverized with ethanol and recrystallized from ethanol to give trans-4-[N-[1-(cyanoimino)propyl]amino]-3,4-dihydro-2,2-dimethyl-3-hydroxy-2H-1-benzopyran-6-carbonitrile (2.81 g).

후처리

  1. temperaturewas refluxed for 10 hours
  2. temperatureThe mixture was cooled
  3. concentrationconcentrated under reduced pressure
  4. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-ef8b4c26a3324654b19cb9e0070fa59c
출처 데이터셋
uspto-grants-1992_04
특허 번호
US05104890

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