Hydrogen Sulfide → 3,5-Di-tert-butyl-4-hydroxyphenyl thioacetamide

HRID 1030226

반응식

HRID 1030226 반응식
[C:1]([C:5]1[CH:6]=[C:7]([CH2:16][C:17]#[N:18])[CH:8]=[C:9]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:10]=1[OH:11])([CH3:4])([CH3:3])[CH3:2].C(N(CC)CC)C.[SH2:26]>N1C=CC=CC=1>[C:12]([C:9]1[CH:8]=[C:7]([CH2:16][C:17]([NH2:18])=[S:26])[CH:6]=[C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])[C:10]=1[OH:11])([CH3:15])([CH3:14])[CH3:13]

참가 물질

5

반응물 3

HCID 402Hydrogen SulfideHCID 8471TriethylamineHCID 615568(3,5-Di-tert-butyl-4-hydroxyphenyl)acetonitrile

생성물 1

HCID 146278133,5-Di-tert-butyl-4-hydroxyphenyl thioacetamide

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

3,5-Di-tert-butyl-4-hydroxyphenylacetonitrile (20.0 g) and 11.4 ml of triethylamine were dissolved in 40 ml of pyridine, and hydrogen sulfide was blown into the solution at room temperature over 13 hours. The reaction mixture was concentrated, and the crude product thus obtained was purified by silica gel column chromatography (diethyl ether-hexane =3:7) to give 4.9 g of the desired compound as a colorless solid.

후처리

  1. concentrationThe reaction mixture was concentrated
  2. customthe crude product thus obtained
  3. customwas purified by silica gel column chromatography (diethyl ether-hexane =3:7)

출처 및 근거

ORD 기록
ord-233302ed76be423e8e7ebd794f843162
출처 데이터셋
uspto-grants-1992_04
특허 번호
US05104889

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