Pyridine → N-[4-(3-Chloro-1-propyloxy)phenyl]methanesulfonamide

HRID 1030275노트

반응식

HRID 1030275 반응식
[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][CH:7]=1.N1C=CC=CC=1.[CH3:19][S:20](Cl)(=[O:22])=[O:21]>C(Cl)Cl>[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][S:20]([CH3:19])(=[O:22])=[O:21])=[CH:8][CH:7]=1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 31297Methanesulfonyl chlorideHCID 198223581-Chloro-3-(4-aminophenoxy)propane

생성물 1

HCID 19822347N-[4-(3-Chloro-1-propyloxy)phenyl]methanesulfonamide수율 90%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

To a cooled (0° C.), stirred solution of 1-chloro-3-(4-aminophenoxy)propane (680 mg, 3.66 mmol) and pyridine (319 mg, 4.03 mmol) in CH2Cl2 (10 mL) was added methanesulfonyl chloride (461 mg, 4.03 mmol). After 18 hours, the mixture was washed with 1N HCl and brine, dried (MgSO4), and concentrated to give 865 mg (90%) of product as an off-white solid m.p. 120°-122° C.

후처리

  1. washthe mixture was washed with 1N HCl and brine
  2. dry with materialdried (MgSO4)
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-0a35b9fe20ce4f99988870b8852a2946
출처 데이터셋
uspto-grants-1992_04
특허 번호
US05104892

반응 노트

불러오는 중…