Sodium Iodide → N-[4-(3-Iodo-1-propyloxy)phenyl]methanesulfonamide

HRID 1030276노트

반응식

HRID 1030276 반응식
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][S:13]([CH3:16])(=[O:15])=[O:14])=[CH:8][CH:7]=1.[I-:17].[Na+]>CC(C)=O>[I:17][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][S:13]([CH3:16])(=[O:15])=[O:14])=[CH:8][CH:7]=1

참가 물질

4

반응물 2

HCID 5238Sodium IodideHCID 19822347N-[4-(3-Chloro-1-propyloxy)phenyl]methanesulfonamide

생성물 1

HCID 19822359N-[4-(3-Iodo-1-propyloxy)phenyl]methanesulfonamide수율 96.7%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A solution of N-[4-(3-chloro-1-propyloxy)phenyl]methanesulfonamide (1.03 g, 3.90 mmol) and sodium iodide (1.75 g, 11.70 mmol) in acetone (15 mL) was heated under reflux for 18 hours. The mixture was concentrated, taken up in EtOAc, and washed with brine, 10% aqueous sodium bisulfite, and brine. The organic phase was dried (MgSO4) and concentrated to give 1.34 g (96%) of product as an off-white solid m.p. 109°-111° C.

후처리

  1. temperatureunder reflux for 18 hours
  2. concentrationThe mixture was concentrated
  3. washwashed with brine, 10% aqueous sodium bisulfite, and brine
  4. dry with materialThe organic phase was dried (MgSO4)
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b9c2efe2389f4fba86b97cbb3cda15c3
출처 데이터셋
uspto-grants-1992_04
특허 번호
US05104892

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