반응식
[C:1]12([C:11]([OH:13])=O)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[C:14]1([CH2:20][N:21]2[CH2:26][CH2:25][N:24]([CH2:27][CH2:28][NH2:29])[CH2:23][CH2:22]2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C(OP(C#N)(=O)OCC)C.C(N(CC)CC)C.[Cl:47]CCl>>[ClH:47].[ClH:47].[C:14]1([CH2:20][N:21]2[CH2:22][CH2:23][N:24]([CH2:27][CH2:28][NH:29][C:11]([C:1]34[CH2:8][CH:7]5[CH2:6][CH:5]([CH2:4][CH:3]([CH2:9]5)[CH2:2]3)[CH2:10]4)=[O:13])[CH2:25][CH2:26]2)[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1참가 물질
실험 절차
To a solution of adamantane-1-carboxylic acid (11.85 g, 0.065 mol) and 2-[4-(phenylmethyl)-1-piperazinyl]ethylamine (12.0 g, 0.054 mol) in dichloromethane (200 mL) at 4° C. was added, with stirring, a solution of diethylcyanophosphonate (11.8 mL, 0.065 mol) in dichloromethane (50 mL), followed by a solution of triethylamine (9.2 mL, 0.065 mol) in dichloromethane (50 mL). The resulting mixture was stirred overnight, during which time it came up to room temperature. The reaction mixture was then washed with 10% aqueous potassium carbonate (200 mL), dried over anhydrous sodium sulfate, and concentrated on a rotary evaporator. The desired product (TLC on silica gel using 10% methanol/ethyl acetate, Rf=0.33) was isolated by crystallization from hexane and recrystallized from hexane. It was then converted to its dihydrochloride salt with isopropanolic HCl (12.71 g, 52%), mp=259°-260° C.
후처리
- stirringThe resulting mixture was stirred overnight, during which time it
- customcame up to room temperature
- washThe reaction mixture was then washed with 10% aqueous potassium carbonate (200 mL)
- dry with materialdried over anhydrous sodium sulfate
- concentrationconcentrated on a rotary evaporator
출처 및 근거
- ORD 기록
- ord-8c980e1938f44627838b33fe721e7a9f
- 출처 데이터셋
- uspto-grants-1992_04
- 특허 번호
- US05106849
연결된 노트
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