Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 3'-Amino-4'-methoxyacetanilide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | 4'-Methoxy-3'-nitroacetanilide | HCID 95043 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 3'-Amino-4'-methoxyacetanilide | HCID 80779 | — |
반응 단계
104 parts of 2-nitro-4-acetamidoanisole, 200 parts of methanol, 1.2 parts of a 30% aqueous solution of ammonia and 2 parts of a 50% suspension of palladium on charcoal, moist with water, in 2 parts of water are charged to an autoclave equipped with an aerating stirrer. The autoclave is pressurised with hydrogen and, at a pressure of 5 bar and a temperature of 100° C., hydrogenation is carried out for 2 hours. 2-Methoxy-5-acetamidoaniline is obtained in quantitative yield in a purity of >97% (analysis by liquid chromatography).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05107022 |
| 출처 데이터셋 | uspto-grants-1992_04 |
| ORD ID | ord-55012430aa88442d939a9871a4d0e78b |
| 출처 메모 | uspto-grants-1992_04 |