Butyl bromide → 2,3-Dichloro-4-methoxy-N-n-butylaniline

HRID 1031137

반응식

HRID 1031137 반응식
[Cl:1][C:2]1[C:8]([Cl:9])=[C:7]([O:10][CH3:11])[CH:6]=[CH:5][C:3]=1[NH2:4].[CH2:12](Br)[CH2:13][CH2:14][CH3:15].C(=O)([O-])O.[Na+]>COCCO>[Cl:1][C:2]1[C:8]([Cl:9])=[C:7]([O:10][CH3:11])[CH:6]=[CH:5][C:3]=1[NH:4][CH2:12][CH2:13][CH2:14][CH3:15]

참가 물질

5

반응물 3

HCID 8002Butyl bromideHCID 516892Sodium BicarbonateHCID 136906392,3-Dichloro-4-methoxyaniline

생성물 1

HCID 136884512,3-Dichloro-4-methoxy-N-n-butylaniline

시약·촉매·용매 1

HCID 80192-Methoxyethanol용매

실험 절차

A mixture of 2,3-dichloro-4-methoxyaniline (19.2 g), n-butylbromide (22.0 g), sodium hydrogen carbonate (40 g) and methylcellosolve (350 ml) is stirred at 95°-100° C. for about 48 hours. The cooled mixture is filtered, and the filtrate is evaporated in vacuo. The remaining material is washed with water and is thereafter recrystallized from ethanol to give the title compound with a melting point of 47°-49° C.

후처리

  1. filtrationThe cooled mixture is filtered
  2. customthe filtrate is evaporated in vacuo
  3. washThe remaining material is washed with water
  4. customis thereafter recrystallized from ethanol

출처 및 근거

ORD 기록
ord-e3504bd97ea84bcfa34630b861623f7f
출처 데이터셋
uspto-grants-1992_04
특허 번호
US05109009

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