Nitric Acid → 5-Chloro-1,3-dimethyl-4-nitro-1H-pyrazole

HRID 1031336

반응식

HRID 1031336 반응식
OS(O)(=O)=O.[Cl:6][C:7]1[N:11]([CH3:12])[N:10]=[C:9]([CH3:13])[CH:8]=1.[N+:14]([O-])([OH:16])=[O:15]>>[Cl:6][C:7]1[N:11]([CH3:12])[N:10]=[C:9]([CH3:13])[C:8]=1[N+:14]([O-:16])=[O:15]

참가 물질

4

반응물 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 5215075-Chloro-1,3-dimethylpyrazole

생성물 1

HCID 2795155-Chloro-1,3-dimethyl-4-nitro-1H-pyrazole

반응 조건

온도
85 °C

실험 절차

Concentrated H2SO4 (35 g) was added to 10 ml of 90% HNO3 and at 75°-85° C., 13 g (0.1 mol) of 5-chloro-1,3-dimethylpyrazole was added dropwise with stirring to maintain the temperature at 85° C. After completion of the addition, the mixture was heated at 75 -85° C. for 1.5 hr. The nitration mixture was cooled and poured into ice. The suspension was filtered and the solid was washed with water and dried to give 14.5 g of the title compound. m.p. 70° C.

후처리

  1. additionAfter completion of the addition
  2. temperaturethe mixture was heated at 75 -85° C. for 1.5 hr
  3. temperatureThe nitration mixture was cooled
  4. additionpoured into ice
  5. filtrationThe suspension was filtered
  6. washthe solid was washed with water
  7. customdried

출처 및 근거

ORD 기록
ord-cd7d66b7bcbb4b85af610717808f9306
출처 데이터셋
uspto-grants-1990_09
특허 번호
US04954164

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